한방병원에 내원한 암환자 52명에 대한 NK cell Activity 특성 분석

• Published in: 대한한방내과학회지 Vol. 39; no. 4; pp. 471 - 479
• Main Authors: 이가영, 김민지, 정진용, 유주영, 조정효, 손창규, 이남헌, Lee, Ga-young, Kim, Min-ji, Joung, Jin-yong, Ryu, Ju-young, Cho, Jung-hyo, Son, Chang-gue, Lee, Nam-hun
• Format: Journal Article
• Language: Korean
• Published: 대한한방내과학회 01.09.2018
• Subjects: 한의학; cancer; clinical characteristics; NK cell activity
• ISSN: 1226-9174

Objectives: This study was aimed to analyze the correlation of clinical characteristics of cancer patients treated with Korean Medicine and their natural killer cell activity (NKA). Methods: The medical records of 52 cancer patients who conducted NKA test at Cheonan Korean Medicine Hospital of Daejeon University from March 2016 to May 2018 were reviewed. NKA was determined at Seegene Medical institute using NK Vue Gold(R) kit, evaluating activated $IFN-{\gamma}$ by enzyme immunoassay after incubation of whole blood. Careful investigations were conducted by categorizing the patients by their sex, origin, stage, ECOG scale, and conventional treatment type. We used data from the medical records and statistical analysis using SPSS 25.0 V. Results: The average NKA of all patients was $623.1{\pm}722.0pg/mL$. The NKA value was higher for females than for males. No correlation was evident between age and NKA, but patients aged over 70 years had the lowest NKA average result. Stage III and IV patients showed clearly lower NKA values when compared to stage I and II patients. NKA and ECOG scale values showed no evident relationship. Conclusions: This study presented the characteristics of NKA in cancer patients treated with Korean medicine. The NKA result differed by gender and stage. Based on these findings, further study is needed regarding the clinical meaning of NKA.