전이암 환자의 예후 판단 인자로서 생체전기 임피던스 분석을 이용한 위상각의 역할

• Published in: 대한한방내과학회지 Vol. 39; no. 4; pp. 463 - 470
• Main Authors: 윤성수, 윤성우, 류한성, 김은혜, 이지영, Yoon, Sung-soo, Yoon, Seong-woo, Ryu, Han-sung, Kim, Eun-hye, Lee, Jee-young
• Format: Journal Article
• Language: Korean
• Published: 대한한방내과학회 01.09.2018
• Subjects: 한의학; phase angle; metastatic cancer; prognostic factor; palliative care; bioelectrical impedence analysis (BIA)
• ISSN: 1226-9174

Objectives: The aim of this study was to identify the validity of phase angle as a prognostic factor for survival in patients with metastatic cancer. Methods: Data of patients with metastatic cancer who visited the Korean medicine cancer center at Kyung Hee University Hospital in Gangdong from April 2016 to February 2018 were collected for this study. The values of phase angle (PhA) and blood hemoglobin (Hb), C-reactive protein (CRP), and serum albumin levels were also investigated by bioelectrical impedance analysis (BIA). Results: In total, 86 patients were analyzed. The cut-off value of the phase angle was determined as 5.0. Univariate and multivariate analysis revealed that phase angle (HR 3.15, 95% CI 1.79-5.54) and CRP (HR 2.15, 95% CI 1.24-3.73) predicted survival with statistical significance. The median overall survival of the low PhA group ($PhA{\leq}5.0$) was 1.8 months (95% CI 0.6-2.9 months) and 7.2 months (95% CI 5.2-9.2 months) in the high PhA group (PhA>5.0)(p<0.001). Conclusions: The phase angle could be an independent prognostic factor for patients with metastatic cancer. Further research is required to confirm these findings and their correlation with other indexes.