Pentacyclic Triterpenoids and Their Cytotoxicity from the Stem Bark of Styrax japonica S. et Z

The methylene chloride soluble fraction of MeOH extract from the stem bark of Styrax japonica S. et Z. (Styracaceae) showed significant cytotoxicity by SRB method against five human tumor cell lines. Four known pentacyclic triterpenoids, oleanolic aldehyde acetate (1), erythrodiol-3-acetate (2), eup...

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Published inArchives of pharmacal research Vol. 27; no. 3; pp. 283 - 286
Main Authors Kim, Mi-Ran, Lee, Hyang-Hee, Hahm, Kyung-Soo, Moon, Young-Hee, Woo, Eun-Rhan
Format Journal Article
LanguageKorean
Published 대한약학회 01.03.2004
Subjects
약학
Styrax japonica
Stem bark
Cytotoxicity
Pentacyclic triterpenoids
Styracaceae
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Summary:The methylene chloride soluble fraction of MeOH extract from the stem bark of Styrax japonica S. et Z. (Styracaceae) showed significant cytotoxicity by SRB method against five human tumor cell lines. Four known pentacyclic triterpenoids, oleanolic aldehyde acetate (1), erythrodiol-3-acetate (2), euphorginol (3), and anhydrosophoradiol -3-acetate (4) were isolated by activity-guided fractionation. Their structures were determined by chemical and spectral analysis. Compounds 1-4 were isolated from S. japonica for the first time.
Bibliography:KISTI1.1003/JNL.JAKO200411922462274
G704-000010.2004.27.3.007
ISSN:0253-6269
1976-3786