Daphnia magna를 이용한 과불화화합물의 독성평가

• Published in: 환경독성보건학회지 Vol. 25; no. 2; pp. 153 - 159
• Main Authors: 김경태, 조재구, 윤준헌, 이철우, 최경희, 김현미, 류지성, Kim, Kyung-Tae, Cho, Jae-Gu, Yoon, Jun-Heon, Lee, Chul-Woo, Choi, Kyung-Hee, Kim, Hyun-Mi, Ryu, Ji-Sung
• Format: Journal Article
• Language: Korean
• Published: 환경독성보건학회 01.06.2010
• Subjects: 기타의약학; Immobility; Perfluorooctanoic acid; Fecundity; Daphnia magna; Perfluorooctane sulfonic acid
• ISSN: 2093-6400

Perfluorooctane sulfonic acid (PFOS) and Perfluorooctanoic acid (PFOA) are the principal chemicals known as perfluoroalkyl acids (PFAs). Despite the widespread use of these compounds, relatively little is known about their fate and effects. The purpose of this study was to determine the toxic effects of PFOS and PFOA on Daphnia magna. In the acute toxicity test, D. magna were exposed for 48 hours at concentrations of 0, 30, 45, 67.5, 101.25 and 151.88 mg/L PFOS, and 0, 100, 160, 225, 337.5 and 506.25 mg/L PFOA, respectively. In the case of chronic toxicity test, D. magna were exposed through water for 21 days at concentrations of 0, 0.375, 0.75, 1.5, 3 and 6 mg/L PFOS, and 0, 1.25, 2.5, 5, 10 and 20 mg/L PFOA, respectively. Acute toxicity was assessed on the basis of immobility, while chronic toxicity was assessed on the basis of fecundity. The acute toxicity test on PFOS and PFOA showed that the values of $EC_{50}$ were 50.90 mg/L and 253.47 mg/L, respectively. In the chronic test, fecundity was reduced significantly at 1.5 mg/L of PFOS and 10 mg/L of PFOA, respectively. These results indicated that PFOS is more toxic to zooplankton than PFOA, and both chemicals have some hazard demonstrates risk for acute or chronic toxicity to freshwater organism.