구강편평태선과 구강작열감증후군의 생체표지자로써 혈장 펜트라신-3의 유용성

• Published in: 대한구강악안면병리학회지 Vol. 48; no. 1; pp. 1 - 8
• Main Authors: 김도연, 우복희, 송재민, 주지영, 옥수민, 박혜련, DoYeon Kim, Bok Hee Woo, Jae-Min Song, Ji-Young Joo, Soo-Min Ok, Hae Ryoun Park
• Format: Journal Article
• Language: English
• Published: 대한구강악안면병리학회 29.02.2024
• Subjects: 치의학; Plasma Pentraxin-3; Biomarker; Burning Mouth Syndrome; Oral Lichen Planus
• ISSN: 1225-1577; 2384-0900

The limitation of markers for chronic oral diseases such as oral lichen planus (OLP) and burning mouth syndrome (BMS) is a diagnostic challenge for clinicians. The pathogenesis of OLP and BMS is not yet fully understood. Therefore, diagnoses are mainly based on the observation of clinical features and history, rather than established markers. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are used to determine the state of inflammation; however, these markers have some limitations. Recently, a new inflammatory marker, pentraxin-3 (PTX3), has been identified in other systemic inflammatory diseases. PTX3 is a member of the pentraxin family and is classified as a long pentraxin. PTX3 is found in various human tissues, whereas the classical short pentraxin, CRP, is secreted only in the liver. PTX3 is a marker of autoimmune diseases and periodontitis. However, there are no studies on PTX3 in OLP and BMS; therefore, we sought to determine if PTX3 can be a diagnostic marker for OLP and BMS. PTX3 was found to be correlated with other inflammatory markers, suggesting its diagnostic value for inflammatory oral diseases. We also found that the PTX3 levels were lower in patients with OLP and BMS. ESR levels were elevated in the OLP and BMS groups, but CRP levels were not. Despite these associations, no correlation was found between PTX3 expression and other known clinical features of OLP and BMS. We suggest that PTX3 plays a role in the immunological and neurological pathways involved in the complex pathogenesis of OLP and BMS.