순기화중탕이 Indomethacin으로 유발된 위궤양에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 17; no. 2; pp. 326 - 337
• Main Authors: 김상찬, 이동언, 권영규, Kim Sang Chan, Lee Dong En, Kwon Young Kyu
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01.04.2003
• Subjects: 한의학; gastric ulcer; Sunkiwhajung-tang; indomethacin
• ISSN: 1738-7698; 2283-2529; 2288-2529

In order to evaluate the prevention effect of Sunkiwhajung-tang (SWT) which has been used as a traditional prescription for the treatment of digestive disease in Korea on the gastric ulcer induced by indomethacin in rats, the changes of number and size of ulcerative lesions, parietal, chief, Grimelius and Serotonin-positive cells in the peri-ulcerative tissues were detected with histological examinations of ulcerative and peri-ulcerative lesions after oral injections of SWT extracts (125, 250 and 500 mg/kg, respectively). SWT prevented to a great extent the expected indomethacin-induced elevation in hemorrhagic ulcerative lesions, the number and size of ulcerative lesions, and the number of parietal cell, chief cell, Grimelius-positive cells and Serotonin-positive cells in the peri-ulcerative lesions in a dose dependent manner. These results provide a story evidence that SWT produced an protective effect on gastric ulcer induced by indomethacin. Determination of the specific mechanisms involved in the protective effect of SWT on the gastric ulcer will require additional study.