Screening of the Positive Inotropic Activity of Medicinal Plants Used in Oriental Medicine

Aqueous extracts of medicinal plants traditionally used in the East Asia such as China, Korea, and Japan were screened for inotropic activity using isolated rabbit atria. Among the twenty-one aqueous-extracts from medicinal plants, the aqueous extracts of Convallaria keiskei(ACK) and rhizome of Copt...

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Published in동의생리병리학회지 Vol. 20; no. 3; pp. 730 - 734
Main Authors Choi, Deok-Ho, Kang, Dae-Gil, Kim, Seung-Ju, Cui, Xun, Lee, Ho-Sub
Format Journal Article
LanguageKorean
Published 한의병리학회 01.06.2006
Subjects
한의학
atrial stroke volume
pulse pressure
inotropic activity
Oriental medicines
cardiac failure
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Summary:Aqueous extracts of medicinal plants traditionally used in the East Asia such as China, Korea, and Japan were screened for inotropic activity using isolated rabbit atria. Among the twenty-one aqueous-extracts from medicinal plants, the aqueous extracts of Convallaria keiskei(ACK) and rhizome of Coptis chinesis (ACC) were found to exhibit distinctive positive inotropic activity. The aqueous extracts of C. keiskei and rhizome of C. chinensis significantly increased atrial stroke volume and pulse pressure in beating rabbit atria. These findings suggest that the aqueous extracts of C. keiskei and rhizome of C. chinensis enhance the cardiac muscle contractility and then could be useful for the treatment of cardiac failure.
Bibliography:KISTI1.1003/JNL.JAKO200603036952396
G704-000534.2006.20.3.002
ISSN:1738-7698
2283-2529
2288-2529