비소세포 폐암과 동반된 부수종양성 변연계뇌염 1예

• Published in: Tuberculosis and respiratory diseases Vol. 63; no. 4; pp. 382 - 386
• Main Authors: 신현종, 김현수, 임금남, 노유석, 최정혜, 김인순, 이영열, 박병배, 박동우, Shin, Hyun Jong, Kim, Hyun Soo, Lim, Keum Nam, Noh, U Seok, Choi, Jung Hye, Kim, In Soon, Lee, Young Yeul, Park, Byeong Bae, Park, Dong Woo
• Format: Journal Article
• Language: Korean
• Published: 대한결핵및호흡기학회 01.10.2007
• Subjects: 내과학; Non-small cell Lung cancer; Paraneoplastic Limbic encephalitis
• ISSN: 1738-3536; 2005-6184

Paraneoplastic limbic encephalitis is a rare disorder that is characterized by personality changes, irritability, depression, seizures, memory loss and dementia, and is commonly associated with small cell lung cancer. The cause is unknown but it is believed to be an autoimmune disorder that develops secondary to a carcinomatous process. We report a patient with the clinical feature consistent with limbic encephalitis. A 64-year-old women developed disorientation, memory loss and general weakness. She was diagnosed with NSCLC (adenocarcinoma) with a brain metastasis 1 year earlier and was treated with radiation and chemotherapy. Although the lung mass and brain metastatic lesions had improved, the brain T2-weighted MRI showed high signal intensity in the right temporal region. This lesion consisted of with limbic encephalitis and was negative to the other viral and immune markers. The patient's symptoms did not improve after steroid treatment. Our case demonstrated that a NSCLC (adenocarcinoma) also can be associated with paraneoplastic limbic encephalitis. 저자들은 이미 비소세포 폐암(선암)을 진단받고 Gefitinib으로 치료중인 여자 환자에서 기억장애, 행동 및 인지기능 장애 등의 증상으로 내원하여 뇌자기공명 소견과 혈청학적 검사로 부수종양성 변연계 뇌염을 진단하였으며 스테로이드 치료에 호전이 없었던 증례를 처음 경험하였기에 보고하는 바이다.