활성산소에 의한 심근독성 및 동과의 보호효과에 관한 연구

To examine the cardiotoxicity of glucose oxidase(GO) in cultured myocardial cells, cardiotoxicity was measured by MTT assay. Myocardial cells were treated with 1～50 mU/ml GO for 5 hours. The cardioprotective effect of Benincasae Semen(BS) was measured by MTT assay in these cultrures. Cell viability...

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Bibliographic Details
Published in동의생리병리학회지 Vol. 16; no. 6; pp. 1197 - 1200
Main Authors 유교상(Kyo Sang Yoo), 손영우(Young Woo Son), 이용석(Yong Suk Lee)
Format Journal Article
LanguageKorean
Published 한의병리학회 2002
Subjects
Benincasae Semen
Glucose oxidase
Myocardial cell
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Summary:To examine the cardiotoxicity of glucose oxidase(GO) in cultured myocardial cells, cardiotoxicity was measured by MTT assay. Myocardial cells were treated with 1～50 mU/ml GO for 5 hours. The cardioprotective effect of Benincasae Semen(BS) was measured by MTT assay in these cultrures. Cell viability was significantly decreased in dose- and time-dependently after myocardial cells were exposed to 30mU/ml GO for 5 hours. In the cardioprotective effect of BS on the cardiotoxicity induced by GO, BS prevented the cardiotoxicity induced by GO in these cultures. From these results, it suggests that GO had cytotoxic effect in cultured myocardial cells and herb extract, BS showed protective effect on GO-induced cardiotoxicity.
Bibliography:KISTI1.1003/JNL.JAKO200217140945837
ISSN:1738-7698
2288-2529
2283-2529