Regulation of [ 3 H]Norepinephrine Release by Opioids in Human Cerebral Cortex
To investigate the receptors mediating the regulation of norepinephrine (NE) release in human cerebral cortex slices, we examined the effects of opioid agonists for ${\mu}$-, ${\delta}$-, and ${\kappa}$-receptors on the high potassium (15 mM)-evoked release of [$^3H$]NE. [$^3H$]NE release induced by...
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Published in | The Korean journal of physiology & pharmacology Vol. 7; no. 1; pp. 1 - 3 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | Korean |
Published |
대한생리학회-대한약리학회
01.01.2003
The Korean Journal of Physiology & Pharmacology Editorial Office |
Subjects | |
Online Access | Get full text |
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Summary: | To investigate the receptors mediating the regulation of norepinephrine (NE) release in human cerebral cortex slices, we examined the effects of opioid agonists for ${\mu}$-, ${\delta}$-, and ${\kappa}$-receptors on the high potassium (15 mM)-evoked release of [$^3H$]NE. [$^3H$]NE release induced by high potassium was calcium-dependent and tetrodotoxin-sensitive. [$D-Pen^2$, $D-Pen^5$]enkephalin (DPDPE) and deltorphin II (Delt II) inhibited the stimulated release of norepinephrine in a dose-dependent manner. However, Tyr-D-Ala-Gly-(Me)Phe-Gly-ol and U69,593 did not influence the NE release. Inhibitory effect of DPDPE and Delt-II was antagonized by naloxone, naltrindole, 7-benzylidenaltrexone and naltriben. These results suggest that both ${\delta}_1$ and ${\delta}_2$ receptors are involved in regulation of NE release in human cerebral cortex. |
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Bibliography: | KISTI1.1003/JNL.JAKO200303039581704 |
ISSN: | 1226-4512 2093-3827 |