Autophagy in neutrophils

Autophagy is a highly conserved intracellular degradation and energy-recycling mechanism that contributes to the maintenance of cellular homeostasis. Extensive researches over the past decades have defined the role of autophagy innate immune cells. In this review, we describe the current state of kn...

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Bibliographic Details
Published inThe Korean journal of physiology & pharmacology Vol. 24; no. 1; pp. 1 - 10
Main Authors Shrestha, Sanjeeb, Lee, Jae Man, Hong, Chang-Won
Format Journal Article
LanguageKorean
Published 대한생리학회-대한약리학회 31.01.2020
The Korean Journal of Physiology & Pharmacology Editorial Office
Subjects
Neutrophil extracellular trap
Neutrophil
Autophagy
Bactericidal activity
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Summary:Autophagy is a highly conserved intracellular degradation and energy-recycling mechanism that contributes to the maintenance of cellular homeostasis. Extensive researches over the past decades have defined the role of autophagy innate immune cells. In this review, we describe the current state of knowledge regarding the role of autophagy in neutrophil biology and a picture of molecular mechanism underlying autophagy in neutrophils. Neutrophils are professional phagocytes that comprise the first line of defense against pathogen. Autophagy machineries are highly conserved in neutrophils. Autophagy is not only involved in generalized function of neutrophils such as differentiation in bone marrow but also plays crucial role effector functions of neutrophils such as granule formation, degranulation, neutrophil extracellular traps release, cytokine production, bactericidal activity and controlling inflammation. This review outlines the current understanding of autophagy in neutrophils and provides insight towards identification of novel therapeutics targeting autophagy in neutrophils.
Bibliography:KISTI1.1003/JNL.JAKO202008071720224
ISSN:1226-4512
2093-3827