Chenodeoxycholic Acid에 의한 파골전구세포의 증식 조절

We investigated the effect of Chenodeoxycholic acid (CDCA) on the proliferation of osteoclast precursor cells. CDCA decreased the proliferation of osteoclast precursor cells through the control of cell cycle regulators such as cyclin D1, p21 and p27. When we checked the signaling pathway, CDCA decre...

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Bibliographic Details
Published inYaghag-hoi-ji Vol. 58; no. 3; pp. 165 - 170
Main Authors 노아롱새미, 임미정
Format Journal Article
LanguageKorean
Published The Pharmaceutical Society Of Korea 30.06.2014
대한약학회
Subjects
CDCA
proliferation
osteoclast precursor cells
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ISSN0377-9556
2383-9457

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Summary:We investigated the effect of Chenodeoxycholic acid (CDCA) on the proliferation of osteoclast precursor cells. CDCA decreased the proliferation of osteoclast precursor cells through the control of cell cycle regulators such as cyclin D1, p21 and p27. When we checked the signaling pathway, CDCA decreased Erk activation in osteoclast precursor cells. Furthermore, two bile acid receptors, FXR and TGR5, were involved in the suppressive effect of CDCA. Taken together, this study suggested that bile acid plays an important role in the proliferation of osteoclast precursor cells.
Bibliography:KISTI1.1003/JNL.JAKO201425852031920
ISSN:0377-9556
2383-9457