메틸수은으로 손상된 골모세포에 대한 홍화의 효과에 관한 연구

• Published in: 동의생리병리학회지 Vol. 16; no. 4; pp. 764 - 767
• Main Authors: 민부기(Bu Ki Min), 홍기연(Gi Youn Hong), 오연균(Yeon Kyun Oh), 신용일(Yong Il Shin), 한선희(Sun Hee Han), 이상복(Sang Bork Lee), 신민교(Min Kyo Shin), 전병훈(Byung Hoon Jeon), 송호준(Ho Jun Song), 류도곤(Do Gon Ryu), 박승택(Seung Taeck Park)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2002
• Subjects: Flos carthami; Methylmercuric chloride; Cultured osteoblast
• ISSN: 1738-7698; 2288-2529; 2283-2529

To evaluate the osteotoxic effect of methylmercuric chloride(MMC) on cultured mouse osteoblasts, cytotoxic effect was measured by MTT assay after cultured mouse osteoblasts were incubated with various concentrations of MMC for 20 hours. The protective effect of Flos Carthami(FC) against MMC-induced osteotoxicity was also examined in these cultures. MMC decreased cell viability of cultured mouse osteoblasts remarkably in a dose- and time-dependent manners. In protective effect of FC was remarkably effective in blocking the osteotoxicity induced by MMC. From aboved the results, it is suggested that MMC induce osteotoxicity, and the selective herba extract such as FC is very effective in blocking MMC-mediated neurotoxicity on cultured mouse osteoblasts.