Unveiling the impact of lysosomal ion channels: balancing ion signaling and disease pathogenesis

• Published in: The Korean journal of physiology & pharmacology Vol. 27; no. 4; pp. 311 - 323
• Main Authors: 정윤아, 김원준, 신나경, 배영민, 위진홍
• Format: Journal Article
• Language: Korean
• Published: 대한생리학회-대한약리학회 31.07.2023; The Korean Journal of Physiology & Pharmacology Editorial Office
• Subjects: Lysosomes; Lysosomal storage diseases; Ion channels; Autophagy
• ISSN: 1226-4512; 2093-3827

Ion homeostasis, which is regulated by ion channels, is crucial for intracellular signaling. These channels are involved in diverse signaling pathways, including cell proliferation, migration, and intracellular calcium dynamics. Consequently, ion channel dysfunction can lead to various diseases. In addition, these channels are present in the plasma membrane and intracellular organelles. However, our understanding of the function of intracellular organellar ion channels is limited. Recent advancements in electrophysiological techniques have enabled us to record ion channels within intracellular organelles and thus learn more about their functions. Autophagy is a vital process of intracellular protein degradation that facilitates the breakdown of aged, unnecessary, and harmful proteins into their amino acid residues. Lysosomes, which were previously considered protein-degrading garbage boxes, are now recognized as crucial intracellular sensors that play significant roles in normal signaling and disease pathogenesis. Lysosomes participate in various processes, including digestion, recycling, exocytosis, calcium signaling, nutrient sensing, and wound repair, highlighting the importance of ion channels in these signaling pathways. This review focuses on different lysosomal ion channels, including those associated with diseases, and provides insights into their cellular functions. By summarizing the existing knowledge and literature, this review emphasizes the need for further research in this field. Ultimately, this study aims to provide novel perspectives on the regulation of lysosomal ion channels and the significance of ion-associated signaling in intracellular functions to develop innovative therapeutic targets for rare and lysosomal storage diseases.