다낭성난소증후군의 인슐린 저항성 치료에 대한 한약 기전 및 빈용 본초 : 동물연구에 대한 체계적 문헌 고찰

• Published in: 대한한방부인과학회지 Vol. 37; no. 2; pp. 35 - 57
• Main Authors: 윤소영, So-yeong Yun, 성주영, Ju-young Sung, 김유민, Yu-min Kim, 유수원, Su-won Yu, 김송백, Song-baek Kim
• Format: Journal Article
• Language: Korean
• Published: 대한한방부인과학회 25.05.2024
• Subjects: Herbal Medicine; Insulin Resistance; Polycystic Ovary Syndrome; Review; 한의학
• ISSN: 1229-4292; 2508-3619

Objectives: This systematic review of animal studies was designed to examine the therapeutic mechanisms of herbal medicines of insulin resistance in Polycystic ovary syndrome and composition of them. Methods: Studies were searched from PubMed, CNKI and Medline up to February 2024. Data was extracted and organized as animal model characteristics, treatment period, experimental and control group settings, evaluation index of treatment, therapeutic mechanism of herbal medicine and Composition of prescription. Results: In the 15 studies finally selected, the herbal medicine used in the study was effective in regulating the insulin resistance index, sex hormones and blood lipid index and improving the histological morphology of the ovaries. The herbal medicine prescriptions used in each of the 15 papers were different, and Salviae Miltiorrhizae Radix (丹參), Wolfiporia cocos (茯苓) and Epimedii Herba (淫羊藿) were most frequently used herbs, 7 times. Conclusions: The results showed that herbal medicine is effective in treating insulin resistance in Polycystic ovary syndrome through several mechanisms. The herbs used in more than 4 papers had effects such as anti-inflammatory, anti-oxidant, estradiol hormone production control and glycolipid metabolism control. More diverse clinical studies on insulin resistance in Polycystic ovary syndrome are needed.