크론병을 동반한 강직척추염에서 발생한 성인형 스틸병 1예

• Published in: Journal of rheumatic diseases Vol. 18; no. 2; pp. 142 - 146
• Main Authors: 김유재, You Jae Kim, 박환성, Hwan Sung Park, 김수정, Su Jeong Kim, 김성수, Sung Soo Kim, 김용길, Yong Gil Kim, 이창근, Chang Keun Lee, 유빈, Bin Yoo
• Format: Journal Article
• Language: Korean
• Published: 대한류마티스학회 30.06.2011
• Subjects: Adult-onset Still`s disease; Ankylosing spondylitis; Crohn`s disease; Sacroiliitis; 내과학
• ISSN: 2093-940X; 2233-4718

Adult-onset Still`s disease (AOSD) is an inflammatory disorder of unknown aetiology characterized by a variety of clinical symptoms. AOSD can precede or occur concomitantly with AS and only a few cases of AOSD with AS have been reported. A 21-year-old man presented with spiking fever, sore throat, arthralgia, maculopapular rash, lymphadenopathy, and chronic inflammatory back pain. His laboratory findings showed marked elevations of liver enzyme, C-reactive protein, erythrocyte sedimentatioin rate, ferritin, and sacroiliitis (grade 2), which were the main characteristics of AOSD and AS. Most symptoms except chronic low back pain were improved after treatment with corticosteroid and disease modifying anti-rheumatic drugs. He was then treated with anti- tumor necrosis factor-alpha (anti-TNF-α) agents to control the disease activity of AS and subsequently showed clinical and serological improvement. This is a first case report of AOSD combined with AS in Korea.