노인 천식에서 혈중 미량 영양소와 임상 양상의 연관성 분석

• Published in: Allergy asthma & respiratory disease pp. 223 - 227
• Main Authors: 이소희, 송우정, 박흥우, 김세훈, 박혜경, 김상헌, 권용은, 김태범, 이병재, 지영구, 최병휘, 조상헌, 김선신
• Format: Journal Article
• Language: Korean
• Published: 대한 소아알레르기 호흡기학회 30.07.2017
• Subjects: 소아과학
• ISSN: 2288-0402; 2288-0410
• DOI: 10.4168/aard.2017.5.4.223

Purpose: The prevalence of asthma in the elderly is rapidly increasing. However, we do not fully understand the pathogenesis of elderly asthma, especially for the roles of micronutrients. This study aimed to evaluate the associations between serum levels of micronutrients, including several vitamins and minerals, and clinical features of the elderly asthmatics. Methods: A total of 317 asthmatics aged 65 or older were enrolled. Serum levels of vitamin D, vitamin B12, folate, Mg, and Se were measured and then the associations between serum micronutrient levels and clinical features of elderly asthmatics were evaluated. Results: Positive correlations with significance among serum levels of vitamin B12, vitamin D, and folate were found. Serum micronutrients levels showed no difference according to the atopic status and symptom severity. The serum folate level was significantly associated with forced expiratory volume in 1 second, and serum vitamin B12 and folate levels were significantly associated with serum total IgE level. Interestingly, elderly asthmatics with exacerbation history showed significantly lower serum levels of vitamin D and Mg, but significantly higher serum levels of Se. Conclusion: Serum levels of micronutrients, such as vitamin D, vitamin B12, Mg, folate, and Se, were significantly associated with some clinical features of elderly asthmatics. Clinical meanings of these associations need to be investigated further. KCI Citation Count: 0