소아 크룹 입원 환자의 병인과 계절적 변동: 6년간의 다기관 후향적 연구(2010–2015년)

• Published in: Allergy asthma & respiratory disease pp. 78 - 85
• Main Authors: 이용주, 김효빈, 김봉성, 김창근, 김철홍, 김형영, 김상영, 김윤선, 박초롱, 서주희, 설인숙, 성명순, 송민섭, 송대진, 안영민, 오혜린, 유진호, 이경석, 이 은, 이주석, 장광천, 장윤영, 정은희, 정혜리, 최성민, 최윤정, 한만용, 양현종, 심정연, 김진택, 대한 소아알레르기 호흡기학회 폐렴·호흡기질환 연구회
• Format: Journal Article
• Language: Korean
• Published: 대한 소아알레르기 호흡기학회 30.04.2019
• Subjects: 소아과학
• ISSN: 2288-0402; 2288-0410

Purpose: Croup is known to have epidemics in seasonal and biennial trends, and to be strongly associated with epidemics of parainfluenza virus. However, seasonal and annual epidemics of croup have not been clearly reported in Korea. This study aimed to examine the seasonal/annual patterns and etiologies of childhood croup in Korea during a consecutive 6-year period. Methods: Pediatric croup data were collected from 23 centers in Korea from 1 January 2010 to 31 December 2015. Electronic medical records, including multiplex reverse transcription polymerase chain reaction (RT-PCR) results, demographics and clinical information were cross-sectionally reviewed and analyzed. Results: Overall, 2,598 childhood croup patients requiring hospitalization were identified during the study period. Among them, a total of 927 who underwent RT-PCR were included in the analysis. Males (61.5%) predominated, and most (63.0%) of them were younger than 2 years of age (median, 19 months; interquartile range, 11–31 months). Peak hospitalization occurred in 2010 and 2012 in even-numbered years, and parainfluenza virus (PIV, 39.7%) was the most common cause of childhood croup requiring hospitalization, followed by respiratory syncytial virus (14.9%), human rhinovirus (12.5%), Mycoplasma pneumonaie (10.6%), and human coronavirus (7.3%). Conclusion: It is concluded that croup hospitalization has a biennial pattern in even-numbered years. PIV may be the most common cause of childhood croup; however, croup epidemics could be attributed to other viruses. KCI Citation Count: 1