안정형 협심증 환자에서 C-반응성 단백질 농도의 증가

• Published in: The Korean journal of medicine Vol. 82; no. 1; pp. 45 - 51
• Main Authors: 김완, Wan Kim, 최은진, Eun Jin Choi, 신민호, Min Ho Shin, 강원유, Won Yu Kang, 황선호, Sun Ho Hwang, 박승욱, Seung Wook Bak
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.01.2012
• Subjects: Atherosclerosis; C-reactive protein; Coronary stenosis; Coronary angiography; 내과학; 동맥경화; C-반응성 단백질; 관동맥 협착; 관상동맥 조영술
• ISSN: 1738-9364; 2289-0769

association between inflammatory markers and the severity of coronary artery disease (CAD) in patients with stable angina pectoris remains controversial. This study explored the relationships between the serum high-sensitivity CRP (hs-CRP) Level and severity of coronary atherosclerosis in patients with stable angina. The study enrolled 377 stable angina patients (298 males, 79 females) undergoing coronary angiography from June 2006 to August 2010. Based on the coronary angiography results, they were divided into two groups according to the diameter of stenosis (DS): Group I (DS ≥ 50%) and Group II (DS < 50%). Multivariate Logistic regression was used to examine the relationship between the hs-CRP level (high hs-CRP ≥ 3.0 mg/L versus Low hs-CRP < 3.0 mg/L) and the severity of coronary stenosis. Group I had higher hs-CRP levels than Group II [median hs-CRP (interquartile range); 0.70 (0.3-1.66) versus 1.11 (0.52-3.41) mg/L, p < 0.001]. After adjusting for major cardiovascular risk factors, a high hs-CRP Level was significantly related to the severity of coronary atherosclerosis (OR 1.95, 95% CI = 1.16-3.30). Our data show that patients with ≥ 50% coronary stenosis have higher hs-CRP Levels than patients with < 50% coronary stenosis and stable angina. Further study is needed to define the role of hs-CRP in the progression of angina pectoris. (Korean J Med 2012;82:45-51)