아토피피부염 환자에서 민들레 추출물 함유제(AF-343)의 효과에 관한 연구

• Published in: Chʻŏnsik mit alrerugi Vol. 30; no. 1; pp. 36 - 42
• Main Authors: 김지현, Ji Hyun Kim, 이혜인, Hye In Lee, 박주희, Ju Hee Park, 임윤영, Yun Young Lim, 김범준, Beom Joon Kim, 임인석, In Seok Lim, 김명남, Myeung Nam Kim, 김현석, Hyun Suck Kim, 김종근, Jong Keun Kim, 한성훈, Sung Hoon Han, 조수묵, Soo Muk Cho, 김
• Format: Journal Article
• Language: Korean
• Published: 대한천식알레르기학회 25.03.2010
• Subjects: Atopic dermatitis; Taraxacum platycarpum; 임상병리학
• ISSN: 1226-8739

Background: Taraxacum platycarpum has been investigated for its antiallergic activity in bronchial asthma, but few studies have been conducted to evaluate its efficacy for the treatment of atopic dermatitis (AD). Objective: This study was designed to evaluate the efficacy of the extracts of Taraxacum platycarpum (AF-343) for the treatment of AD. Method: Seventy-five patients with AD were randomly assigned either to a low-dose, high-dose or control groups. AF-343 and placebo were ingested for 8 weeks. The SCORing Atopic Dermatitis (SCORAD) scores, skin hydration, transepidermal water loss (TEWL), eosinophil, total IgE, eosinophil catinonic protein and cytokines were measured before and at the end of treatment. Result: A significant reduction in the SCORAD scores at the end of treatment were observed in the control, low-dose and high-dose groups when compared with the initial scores (P=0.028, P＜0.001 and P＜0.001, respectively). High-dose treatment increased the skin hydration (P=0.013), but no significant change was observed in the low-dose and control groups (P=0.056 and P=0.624, respectively). The low-dose and high-dose treatment groups showed a significant reduction of TEWL from baseline (P=0.002 and P=0.031, respectively). High-dose treatment induced an increase in eotaxin and a decrease in IL-5 (P=0.021 and P=0.028, respectively). Conclusion: These results show that AF-343 treatment can improve the severity and skin hydration in patients with mild AD. (Korean J Asthma Allergy Clin Immunol 2010;30: 36-42)