피부병변과 다발성 뇌경색을 동반한 특발성 호산구 증다증 1예

• Published in: The Korean journal of medicine Vol. 74; no. 3; pp. 336 - 341
• Main Authors: 장선익, Sun Ik Jang, 조일권, Il Kwan Cho, 박상준, Sang Jun Park, 김정현, Jung Hyun Kim, 최승호, Sung Ho Choi, 김선영, Sun Young Kim, 정성창, Sung Chang Jung
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.03.2008
• Subjects: Cerebral infarction; Hypereosinophilic syndrome; Skin lesion; 내과학; 뇌경색; 피부병변; 호산구 증다증
• ISSN: 1738-9364; 2289-0769

Idiopathic hypereosinophilic syndrome (IHES) is a rare systemic disorder that`s characterized by peripheral eosinophilia and eosinophilic infiltration of multiple organs, including the heart, lungs, skin, liver, gastrointestinal tract and nervous system. IHES is associated with a broad range of clinical findings, depending on the involved organ and the severity of the infiltration. The diverse modes of clinical presentation occasionally lead to a false clinical diagnosis. There are no specific tests for diagnosing IHES, and the therapies remain controversial. In this report, we describe a 34-year-old man with IHES that was associated with multiple brain infarctions in both cerebral and cerebellar hemispheres. Five months earlier, the patient presented with erythematous scaly hyperkeratotic skin lesions on both legs. He was treated with anticoagulation therapy, aspirin and topical corticosteroid for about 1 month. All his symptoms and signs dramatically improved, except for the persistent peripheral eosinophilia. On follow-up after 8 months, the patient remained well without relapse or new lesions. (Korean J Med 74:336-341, 2008)