5-Fluorouracil을 투여한 대장암 환자에서 총정맥영양공급치료 중에 발생한 베르니케 뇌병증 2예

Wernicke`s encephalopathy (WE) caused by thiamine deficiency is an acute neurological disorder. Clinically, the classic triad of WE consists of ophthalmoplegia, ataxia, and mental status changes. Thiamine deficiency is known to occur commonly in chronic alcoholic patients. Sometimes, it can occur in...

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Published inThe Korean journal of gastroenterology Vol. 64; no. 3; pp. 158 - 163
Main Authors 조경표, Kyung Pyo Cho, 이재성, Jae Sung Lee, 성지석, Ji Seok Seong, 우용문, Yong Moon Woo, 조영준, Young Jun Cho, 정범진, Beom Jin Jeong, 손지훈, Jee Hoon Sohn, 김수정, Su Jung Kim
Format Journal Article
LanguageKorean
Published 대한소화기학회 30.09.2014
Subjects
Colonic neoplasms
Fluorouracil
Thiamine
Total parenteral nutrition
Wernicke encephalopathy
내과학
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ISSN1598-9992
2233-6869

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Summary:Wernicke`s encephalopathy (WE) caused by thiamine deficiency is an acute neurological disorder. Clinically, the classic triad of WE consists of ophthalmoplegia, ataxia, and mental status changes. Thiamine deficiency is known to occur commonly in chronic alcoholic patients. Sometimes, it can occur in patients after gastrointestinal surgery and in those with malabsorption. In addition, patients undergoing renal dialysis, suffering from hyperemesis gravidarum, receiving total parenteral nutrition (TPN), and being treated with chemotherapeutic agents are also prone to develop thiamine deficiency. Herein, we report two cases of WE that developed following simultaneous 5-fluorouracil (5-FU) chemotherapy and TPN in colon cancer patients which was successfully treated with thiamine administration. (Korean J Gastroenterol 2014;64:158-163)
Bibliography:Korean Society of Gastroenterology
G704-000307.2014.64.3.001
ISSN:1598-9992
2233-6869