저분자량 헤파린 사용에 있어 신기능 정도에 따른 출혈경향 연구

• Published in: Kidney research and clinical practice Vol. 30; no. 2; pp. 155 - 162
• Main Authors: 송은주, Eun Ju Song, 이승엽, Seung Yup Lee, 정유민, Yu Min Jung, 노경우, Kyung Woo Nho, 성수아, Su Ah Sung, 황영환, Young Hwan Hwang, 이소영, So Young Lee
• Format: Journal Article
• Language: Korean
• Published: 대한신장학회 30.03.2011
• Subjects: Bleeding; Low molecular weight heparin; Renal insufficiency; 내과학
• ISSN: 2211-9132; 2211-9140

Purpose: Low molecular weight heparin (LMWH) is safe and effective in the treatment of acute coronary syndrome (ACS) and venous thromboembolism. Compared with unfractionated heparin (UFH), it is known to have less bleeding tendency in the general population. However, it is not certain whether bleeding complications are decreased by LMWH in patients with renal failure. We postulated that the use of LMWH may lead to increase in bleeding tendency in patients with renal dysfunction. Methods: We conducted a retrospective study in 486 hospitalized patients who were diagnosed as cerebral infarction or ACS, and treated with enoxaparin or nadroparin from January 2008 to December 2009. Bleeding complications were compared in 3 groups according to estimated glomerular filtration rate (GFR 60, 30-59, and <30 mL/min/1.73m ≥ 2). Age, hypertension (HTN), diabetes mellitus (DM), smoking and usage of antithrombotics were examined and the relationship of these variables with bleeding tendency was analyzed. Results: Compared with group I, the frequency of total bleeding complications increased in patients with group II (p=0.002) and III (p=0.005) regardless of adequate dose reduction. Multiple logistic regression analysis after adjustment for age, HTN, DM, and usage of antithrombotics revealed that decreased GFR groups [odds ratio (OR) of group II was 5.79 (95% confidence interval (CI), 1.23-29.97; p=0.042), OR of group III 5.92 (95% CI, 1.22-27.61; p=0.029)] and DM [OR of DM 7.88 (95% CI; 1.46-46.32, p=0.026)] were two independent factors which affect major bleeding. Conclusion: These findings suggest that renal insufficiency, even if it is mild, could affect major bleeding complications in the use of LMWH.