마이코페놀릭산 병합요법으로 조절된 면역글로불린 G4 연관성 질환

• Published in: The Korean journal of medicine Vol. 89; no. 6; pp. 690 - 694
• Main Authors: 김지은, Ji Eun Kim, 차진주, Jin Joo Cha, 김선우, Sun Woo Kim, 홍유아, Yu Ah Hong, 고강지, Gang Jee Ko, 권영주, Young Joo Kwon
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.12.2015
• Subjects: Eosinophilia; IgG4; MPA; Mycophenolic acid; 내과학
• ISSN: 1738-9364; 2289-0769
• DOI: 10.3904/kjm.2015.89.6.690

IgG4-related disease (IgG4-RD) is a group of fibro-inflammatory diseases affecting multiple organ systems, pathologically characterized by tissue infiltration with abundant IgG4-positive cells. We here report a case of IgG4-RD that was successfully controlled by mycophenolic acid (MPA). A 62-year-old male visited complaining of dizziness and loss of appetite. He had a clinical history of autoimmune pancreatitis treated with steroids and cyclophosphamide 5 years prior, and had also been diagnosed with Hashimoto’s thyroiditis at the age of 55 years. We initially prescribed prednisolone (1 mg/kg), tapered to 5 mg/day over 8 months. However, his eosinophilia gradually deteriorated, and we added cyclophosphamide (1 mg/kg daily) for the next 7 months. His laboratory data fluctuated when he was on low-dose predinisolone and cyclophosphamide, and we thus changed his medication to prednisolone combined with MPA for the following 63 months. Currently, his laboratory findings are stable. (Korean J Med 2015;89:690-694)