대량의 위궤양 출혈을 일으킨 정상 신생아

• Published in: The Korean journal of gastroenterology Vol. 48; no. 3; pp. 210 - 214
• Main Authors: 박영실, Young Sil Park, 정우철, Woo Chul Chung, 이강문, Kang Moon Lee, 이보인, Bo In Lee, 천지성, Ji Sung Chun, 장우임, U Im Chang, 양진모, Jin Mo Yang, 최규용, Kyu Yong Choi, 정인식, In Sik Chung
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 30.09.2006
• Subjects: Gastric ulcer; Helicobacter pylori; Infant; Pediatric endoscopy; 내과학
• ISSN: 1598-9992; 2233-6869

Gastric ulcer bleeding in neonatal period, mainly in preterm newborn babies or in neonates treated in intensive care units, is relatively frequent, However the occurrence of significant gastric ulcer bleeding in healthy full term infants is unusual. We experienced a case of massive upper gastrointestinal (GI) bleeding in a 3-day-old healthy full term infant. Endoscopic examination confirmed the presence of gastric ulcerations. Treatment was initiated with transfusion and histamine 2 receptor antagonist, and the clinical signs resolved. Mother`s serum antibody to Helicobacter pylori (H. pylori) was positive. We collected stool of the patient including other 17 infants in the intensive care unit. A highly sensitive semi-nested PCR for H. pylori DNA was performed, but all infants including the patient revealed negative. H. pylori infection is not related with upper GI bleeding in healthy full term infants. In conclusion, the diagnosis of upper GI bleeding in infant can be easily made by means of pediatric endoscopy, which is a simple and a well tolerated examination. (Korean J Gastroenterol 2006;48:210-214)