췌장 종괴를 형성하고 스테로이드에 호전을 보인 2형 자가면역 췌장염

• Published in: The Korean journal of gastroenterology Vol. 58; no. 1; pp. 53 - 57
• Main Authors: 전연주, Yeon Joo Chun, 장재혁, Jae Hyuck Chang, 이인석, In Seok Lee, 이장은, Jang Eun Lee, 정문경, Mun Kyung Chung, 정찬권, Chan Kwon Jung, 최명규, Myung Gyu Choi, 정인식, In Sik Chung
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 30.07.2011
• Subjects: Autoimmune diseases; Pancreatitis; 내과학
• ISSN: 1598-9992; 2233-6869

Autoimmune pancreatitis (AIP) has two distinct subsets. Type 1 AIP or lymphoplasmacytic sclerosing pancreatitis is systemic disease with the elevation in serum levels of the IgG4. Type 2 AIP, also called duct-centric pancreatitis, features granulocyte epithelial lesions with duct obstruction in the pancreas without systemic involvement. Here, we report a case of type 2 AIP diagnosed by pathology, which is the first report in Korea. The case is a 56-year-old woman who presented with anorexia and vomiting. Computed tomography revealed mass-like lesion in the pancreatic head and the compression of the distal common bile duct and the head portion of the main pancreatic duct. Serum levels of the IgG4 were normal. Histologic examination revealed a dense neutrophil infiltration in the pancreatic parenchyme associated with extensive fibrosis, thereby confirming the diagnosis of type 2 AIP. The abnormalities in the clinical, laboratory, and radiological findings improved after oral steroid treatment. (Korean J Gastroenterol 2011;58:53-57)