IL-4와 IFN-γ 유전자 다형성들의 아토피에 대한 상호 작용 모형

• Published in: Chʻŏnsik mit alrerugi Vol. 28; no. 1; pp. 45 - 52
• Main Authors: 이준혁, June Hyuk Lee, 최종효, Jong Hyo Choi, 윤진아, Jin A Yoon, 박성우, Sung Woo Park, 김도진, Do Jin Kim, 장안수, An Soo Jang, 박종숙, Jong Sook Park, 어수택, Soo Taek Uh, 임태연, Tai Youn Rhim, 김용훈, Yong Hoon Kim, 신형두, Hyoung Doo Shin
• Format: Journal Article
• Language: Korean
• Published: 대한천식알레르기학회 30.03.2008
• Subjects: Atopy; Epistasis; IFN-gamma; IL-4; Polymorphism; 임상병리학
• ISSN: 1226-8739

Background: Asthma is a common complex genetic disease. While the T-helper cell 1 pathway is determined by cytokine interferon-gamma (IFN-γ), the T-helper cell 2 pathway is determined by IL-4. These comprise two alternative CD4+ T-cell fates with functional consequences for the host immune system. We investigated the effect of interaction between and IL-4 SNPs on asthma or atopy. Method: Three hundred asthmatics and 300 unrelated normal controls were enrolled. Two candidate SNPs of the IFN-γ gene and two SNPs of the IL-4 gene were selected. Gene-gene interactions were tested using the multi-factor dimensionality reduction (MDR) method and interaction information analysis on the basis of Shannon entropy. Result: In MDR analysis, a combination of IFN-γ+2459A＞G and IL-4-589C ＞T was the best model to predict atopy. In interaction information analysis, there was a strong effect of interaction between theses two SNPs on atopy. This combination showed a stronger effect than each SNP alone. In addition, IL-4-589C ＞T showed a strong effect on atopy with IFN- γ+2671C ＞T and with IFN- γ+2459A ＞G. Theses effects were prominent in normal controls. Conclusion: From the findings of a statistical interaction model, it is suggested that IFN-γ and IL-4 gene SNPs may contributes to the development of atopy by interacting with each other. (Korean J Asthma Allergy Clin Immunol 2008;28:45-52)