유도객담에서 호산구 증가가 있는 만성 기침 환자의 원인 분석

• Published in: Chʻŏnsik mit alrerugi Vol. 27; no. 2; pp. 125 - 130
• Main Authors: 손성욱, Seong Wook Sohn, 양민석, Min Seok Yang, 이소희, So Hee Lee, 송우정, Woo Jung Song, 이상민, Sang Min Lee, 권혁수, Hyouk Soo Kwon, 김덕인, Deok In Kim, 박창한, Chang Han Park, 박흥우, Heung Woo Park, 장윤석, Yoon Seok Chang, 김선신, Sun Sin
• Format: Journal Article
• Language: Korean
• Published: 대한천식알레르기학회 30.06.2007
• Subjects: Asthma; Chronic cough; Eosinophilic bronchitis; Sputum eosinophilia; UACS; 임상병리학
• ISSN: 1226-8739

Background: Eosinophilic bronchitis (EB) is recently regarded as an important cause of chronic cough. However, sputum eosinophilia is commonly encountered in the other causes of chronic cough such as upper airway cough syndrome (UACS) and asthma. Objective: To evaluate the cause of chronic cough with sputum eosinophilia. Method: We investigated patients with chronic cough. Induced sputum, methacholine bronchial provocation test, skin prick test, throat examination, chest X-ray, paranasal sinus (PNS) x-ray and rhinoscopy were performed. Result: Sputum was induced in 287 patients. Sputum eosinophilia greater than 3% was present in 117 (40.8%) patients. Among 117 patients with sputum eosinophilia, eosinophilic asthma was diagnosed in 36 (30.8%) patients, chest X-ray abnormality or ACEI use was detected in 18 (15.4%) patients, and the remaining 63 (53.8%) patients could be considered to have EB. Among 63 patients with EB, UACS and GERD were found to be combined in 48 (76.2%) and 2 (3.2%) patients, respectively. EB alone without the other causes was diagnosed in 13 (11.1%) patients. Among total 287 patients, EB was detected in 22.0%, and EB alone without the other causes in 4.5%. Conclusion: Sputum eosinophilia can be frequently detected in chronic cough. EB is the common cause in chronic cough with sputum eosinophilia. However, EB is likely to be associated with UACS, which should be considered in cases of EB. (Korean J Asthma Allergy Clin Immunol 2007;27:125-130)