Effects of Galgunhaejutang on Alcohol Consumption in C57BL/6 Mice

• Published in: 동의신경정신과학회지 Vol. 24; no. 3; pp. 263 - 270
• Main Authors: Cho, Seung-Hun, Kim, Hyeun-Kyeung, Kim, Jong-Woo, Whang, Wei-Wan, Kim, Sung-Gon
• Format: Journal Article
• Language: Korean
• Published: 대한한방신경정신과학회 30.09.2013
• Subjects: 6; Alcohol consumption; C57BL; Herbal mixture; Korean traditional medicine; Korean traditional medicine; Herbal mixture; Alcohol consumption; C57BL/6
• ISSN: 1226-6396; 2234-4942

Objectives： Galgunhaejutang extract (GHT) is a Traditional Korean medical herbal mixture that has been tradtionally used to treat alcohol consumption. This study was preformed to evaluate the effects of GHT on alcohol consumption in C57BL/6 mice. Methods： Sixty three C57BL/6 mice were alcohol dependence-induced by limited access paradigm. Water, GHT 0.688 g/kg (GHT-L), or GHT 3.45 g/kg (GHT-H) were administrated for 10 days. The amounts of alcohol consumption for 2 hours, water consumption for 22 hours, food intake for 24 hours and body weight were measured. Results： There weren`t significant differences in 2 hours of alcohol consumption, 22 hours of water consumption, 24 hours of food intake and body weight for ten days between vehicle group and GHT-L or GHT-H group. Conclusions： Further studies employing multi-dose and long term administration of GHT (more than 10 days) might be of benefit.