Screening of Potent Anti-dementia Acetylcholinesterase Inhibitor-containing Edible Mushroom Pholiota adiposa and the Optimal Extraction Conditions for the Acetylcholinesterase Inhibitor

To develop a new anti-dementia acetylcholinesterase (AChE) inhibitor from edible mushrooms, AChE inhibitory activities were determined on water and ethanol extracts of various edible mushrooms from oriental medicine markets and agriculture markets. As a result, the 70% ethanol extract from Pholiota...

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Bibliographic Details
Published inHangug gynnhaghoi ji Vol. 44; no. 4; pp. 314 - 317
Main Authors Kim, Do-Yeon, Bae, Sang-Min, Han, Sang-Min, Lee, Jong-Soo
Format Journal Article
LanguageKorean
Published 한국균학회 31.12.2016
Subjects
Acetylcholinesterase Inhibitor
Anti-dementia
Ethanol extract
Pholiota adiposa
Pholiota adiposa
Ethanol extract
Anti-dementia
Acetylcholinesterase Inhibitor
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Summary:To develop a new anti-dementia acetylcholinesterase (AChE) inhibitor from edible mushrooms, AChE inhibitory activities were determined on water and ethanol extracts of various edible mushrooms from oriental medicine markets and agriculture markets. As a result, the 70% ethanol extract from Pholiota adiposa fruiting body had the highest AChE inhibitory activity of 30.6, and its water extract also had an AChE inhibitory activity of 23.8%. Therefore, we finally selected P. adiposa as a potent anti-dementia AChE inhibitor-containing mushroom. The AChE inhibitor of P. adiposa was maximally extracted when its fruiting body was treated with water for 3hr at 70oC and 70% ethanol for 12 hr at 70oC, respectively.
Bibliography:The Korean Society of Mycology
KISTI1.1003/JNL.JAKO201609636669569
ISSN:0253-651X
2383-5249