Forsythiae Fructus and Its Active Component, Arctigenin, Provide Neuroprotection by Inhibiting Neuroinflammation

In this study, we found that Forsythiae fructus (FF) and one of its main compounds, arctigenin, signifi cantly inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Arctigenin also suppressed the expression of inducible nitric oxide synthase and cyclooxygena...

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Published inBiomolecules & therapeutics Vol. 19; no. 4; pp. 425 - 430
Main Authors Park, Ji-Ho, Hong, Ye-Ji, Moon, Eun-Jung, Kim, Seul-A, Kim, Sun-Yeou
Format Journal Article
LanguageKorean
Published 한국응용약물학회 31.10.2011
Subjects
Arctigenin
Forsythiae fructus
Microglia
Neuroinfl ammation
Neuroprotection
Arctigenin
Neuroprotection
Neuroinflammation
Forsythiae fructus
Microglia
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Summary:In this study, we found that Forsythiae fructus (FF) and one of its main compounds, arctigenin, signifi cantly inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Arctigenin also suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2, and inhibited the activation of extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38. Moreover, it also reduced levels of proinfl ammatory cytokines, interleukin 1β, tumor necrosis factor α and prostaglandin E2, and inhibited neuronal death in LPS-treated organotypic hippocampal cultures. Therefore, we suggest that arctigenin may confer a neuroprotective effect via the inhibition of neuroinfl ammation.
Bibliography:The Korean Society of Applied Pharmacology
KISTI1.1003/JNL.JAKO201130856168039
ISSN:1976-9148
2005-4483