Zipeprol(레스피렌®)을 탐닉하던 노인의 급성 중독 사망례

• Published in: 대한임상독성학회지 Vol. 7; no. 2; pp. 172 - 175
• Main Authors: 이두환, Doo Hwan Lee, 최상천, Sang Cheon Choi, 안정환, Jung Hwan Ahn, 조영신, Young Shin Cho, 김기운, Gi Woon Kim, 민영기, Young Gi Min, 정윤석, Yoon Seok Jung
• Format: Journal Article
• Language: Korean
• Published: 대한임상독성학회 30.12.2009
• Subjects: Old; Poisoning; Zipeprol; Zipeprol; Old; Poisoning
• ISSN: 1738-1320; 2508-6332

Zipeprol dihydrochloride is a non-opioid mucolytic, antitussive agent and it is frequently prescribed for respiratory symptoms such as cough and sputum. The main pharmacologic mechanisms of zipeprol are inhibition of superior laryngeal nerve stimulation and direct antagonism for stimulation of the bronchial receptors, which might have an effect for the drug’s mucolytic action. Many cases of drug abuse with zipeprol have occurred world-wide due to the hallucinogenic effect of the drug. In Korea, zipeprol was reported to be the most commonly abused drug among young people for the 1990s. Zipeprol associated death was first reported since 1991 and 69 cases of death related to zipeprol abuse were further reported during 8 years (between 1991 and 1998). In addition to the hallucinogenic effect, dyspnea, extrapyramidal symptoms, seizure, cerebral edema have been reported as the signs and symptoms of toxic zipeprol overdose. However, zipeprol abuse is not common for old age people and non drug abusers. We report here on a fatal case of acute zipeprol poisoning in an eighty five year old drug addicted woman.