Effects of Rutaecarpine on the Pharmacokinetics of Caffeine and Its Three Metabolites in Rats

Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been shown to be anti-inflammatory. In the present study, a possible interaction between rutaecarpine and caffeine was investigated in male Sprague Dawley rats. Twenty four hr after the oral pretreatment wi...

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Published inBiomolecules & therapeutics Vol. 19; no. 2; pp. 243 - 247
Main Authors Seo, Young-Min, Noh, Keum-Han, Kong, Min-Jeong, Lee, Dae-Hun, Kang, Mi-Jeong, Jahng, Yurng-Dong, Kang, Won-Ku, Jeong, Byeong-Seon, Jeong, Tae-Cheon
Format Journal Article
LanguageKorean
Published 한국응용약물학회 30.04.2011
Subjects
Caffeine
In vivo
Intravenous
Pharmacokinetics
Rat
Rutaecarpine
In vivo
Rat
Pharmacokinetics
Intravenous
Rutaecarpine
Caffeine
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Summary:Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been shown to be anti-inflammatory. In the present study, a possible interaction between rutaecarpine and caffeine was investigated in male Sprague Dawley rats. Twenty four hr after the oral pretreatment with rutaecarpine at 80 mg/kg for three consecutive days, rats were treated intravenously with 10 mg/kg of caffeine. Compared with control rats, the pharmacokinetic parameters of caffeine in rutaecarpine-pretreated rats were significantly changed, possibly due to the rapid metabolism. The production of three metabolites of caffeine (i.e., paraxanthine, theobromine and theophylline) was also significantly changed in rats pretreated with rutaecarpine. The present results suggest that oral rutaecarpine would change the intravenous pharmacokinetic characteristics of caffeine.
Bibliography:The Korean Society of Applied Pharmacology
KISTI1.1003/JNL.JAKO201115952329197
ISSN:1976-9148
2005-4483