Genome-Wide Identification of Haploinsufficiency in Fission Yeast

Abnormal phenotypes resulting from haploinsufficiency (HI) are due to the loss of one allele. Recent studies in budding yeast have shown that HI originates from insufficient protein levels or from a stoichiometric imbalance between subunits of protein complexes. In humans, however, HI often involves...

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Published inJournal of microbiology and biotechnology Vol. 18; no. 6; pp. 1059 - 1063
Main Authors Baek, Seung-Tae, Han, Sang-Jo, Nam, Mi-Young, Kim, Young-Dae, Kim, Li-La, Lee, Hyun-Jee, Heo, Kyung-Sun, Lee, Hye-Mi, Lee, Min-Ho, Park, Song-Kyu, Maeng, Pil-Jae, Park, Young-Woo, Lee, Sung-Hou
Format Journal Article
LanguageKorean
Published 한국미생물생명공학회 30.06.2008
Subjects
Genome-wide
haploinsufficiency
ontology
yeast
Genome-wide
haploinsufficiency
ontology
yeast
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Summary:Abnormal phenotypes resulting from haploinsufficiency (HI) are due to the loss of one allele. Recent studies in budding yeast have shown that HI originates from insufficient protein levels or from a stoichiometric imbalance between subunits of protein complexes. In humans, however, HI often involves transcription factors. Therefore, the species differences in HI and the molecular mechanisms of species-specific HI remain under investigation. In this study, HI in fission yeast was systematically surveyed. HI in fission yeast affected genes related to signaling and to basic cellular processes, as observed in budding yeast. These results suggest that there are species differences in HI and that the HI that occurs in fission yeast is intermediate to HI in budding yeast and humans.
Bibliography:The Korean Society for Applied Microbiology
KISTI1.1003/JNL.JAKO200828837392927
ISSN:1017-7825
1738-8872