The soma-germline communication: implications for somatic and reproductive aging

Aging is characterized by a functional decline in most physiological processes, including alterations in cellular metabolism and defense mechanisms. Increasing evidence suggests that caloric restriction extends longevity and retards age-related diseases at least in part by reducing metabolic rate an...

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Published inBMB reports Vol. 54; no. 5; pp. 253 - 259
Main Authors Gaddy, Matthew A, Kuang, Swana, Alfhili, Mohammad A, Lee, Myon Hee
Format Journal Article
LanguageKorean
Published 생화학분자생물학회 31.05.2021
Subjects
Aging
Germline
Reproduction
Soma
Soma theory
Soma theory
Aging
Reproduction
Germline
Soma
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Summary:Aging is characterized by a functional decline in most physiological processes, including alterations in cellular metabolism and defense mechanisms. Increasing evidence suggests that caloric restriction extends longevity and retards age-related diseases at least in part by reducing metabolic rate and oxidative stress in a variety of species, including yeast, worms, flies, and mice. Moreover, recent studies in invertebrates - worms and flies, highlight the intricate interrelation between reproductive longevity and somatic aging (known as disposable soma theory of aging), which appears to be conserved in vertebrates. This review is specifically focused on how the reproductive system modulates somatic aging and vice versa in genetic model systems. Since many signaling pathways governing the aging process are evolutionarily conserved, similar mechanisms may be involved in controlling soma and reproductive aging in vertebrates. [BMB Reports 2021; 54(5): 253-259]
Bibliography:Korean Society for Biochemistry and Molecular Biology
KISTI1.1003/JNL.JAKO202117242221846
ISSN:1976-6696
1976-670X