재조합 단백질을 이용한 HPV 6b와 16감염의 혈청학적 진단

• Published in: Journal of bacteriology and virology Vol. 24; no. 1; pp. 1 - 7
• Main Authors: 윤희식, 박순희, 최용경, 권두한, 김재화, 최인성, 정태화, 박종섭, 정노팔
• Format: Journal Article
• Language: Korean
• Published: 대한바이러스학회 01.01.1994
• Subjects: Human Papilloma virus type 6b and 16 Serodiagnosis Recombinant protein; type 6b and 16 Serodiagnosis; Recombinant protein; Human Papilloma virus
• ISSN: 1598-2467; 2093-0429

Recently the investigation of the immune responses to Human papillomavirus(HPV) infection has been employed to identify serological markers that are associated with anogenital malignancies and/or disease progression. We investigated serological responses in sera from Korean women with or without a history of cervical carcinoma. We used bacterially derived trpE fusion proteins as antigens for Western blot assays. Among women with cancer, 16/32(50%) and 20/32(63%) were positive for antibodies to at leat one of gene products of HPV 16 in the sera of cervical cancer patients were 47% (15/32; E4), 19%(6/32; E6), 38%(12/32; E7), 22% (7/32; Ll), and 6%(2/32; L2), respectively, while none for E4, E6 and L2, 2/20 for E7(10%), and 1/20 for Ll(5%) among the cancer-free individuals. The detection rate of antibodies to the HPV 16 appeared to be higher in the cervical carcinomas, implying the correlation between HPV 16 and cervical carcinoma, although the stastical significance of this interpretation should wait for the analysis of more cases.