한국형 (韓國型) 출혈열 (出血熱) - II . 병원체 (病原體) 분리 (分離)

• Published in: Journal of bacteriology and virology Vol. 7; no. 1; pp. 31 - 42
• Main Authors: 이호왕, 李鎬汪, 이평우, 李平佑
• Format: Journal Article
• Language: Korean
• Published: 대한바이러스학회 30.12.1977
• ISSN: 1598-2467; 2093-0429

Epidemic hemorrhagic fever was recognized for the first time in Korea in 1951 and since that time it has been known as Korean hemorrhagic fever (KHF). Similar diseases to KHF have been known in Manchuria, the Soviet Union, Scandinavia, Eurasia and Japan. Many attempts bave been made to isolate the causative agent of KHF and clinically similar diseases but failed. In 1976 Lee and Lee succeeded in demonstrating an antigen in the lungs of the striped field mouse, Apodemus agrarius, which gave immunofluorescent reactions with sera of patients convalescent from KHF for the first time and named it as Korea antigen. Seventy-three strains of the etiologic agent of KHF which reacted specifically only with the convalescent sera of KHF patients were isolated from lung tissues of Apodemus agrarus coreae rodents and also same agents were isolated from acute sera of two patients in adult Apodemus. The agent was successfully propagated in Apodemus through 13 passages. Experimentally inoculated mice developed sp cific fluorescent antigen in lungs, kidneys, liver, parotid glands, bladder. The agent was neutralized with convalescent serum of KHF, chloroform sensitive, passed through 0.1p millipore filter and not sensitive to antibiotics. The results indicate that the agent is the causative agent of KHF and a small virus.