The Antiproliferation Activity of Ganoderma formosanum Extracts on Prostate Cancer Cells

Androgen-independent prostate cancer accounts for mortality in the world. In this study, various extracts of a medical fungus dubbed Ganoderma formosanum were screened for inhibition of DU145 cells, an androgen-independent prostate cancer cell line. Results demonstrated that both hexane (GF-EH) and...

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Published inMycobiology Vol. 48; no. 3; pp. 219 - 227
Main Authors Chiang, Cheng-Yen, Hsu, Kai-Di, Lin, Yen-Yi, Hsieh, Chang-Wei, Liu, Jui-Ming, Lu, Tze-Ying, Cheng, Kuan-Chen
Format Journal Article
LanguageKorean
Published 한국균학회 30.06.2020
Subjects
apoptosis
cell cycle arrest
cyclin
Ganoderma formosanum
Prostate cancer
apoptosis
cyclin
Ganoderma formosanum
cell cycle arrest
Prostate cancer
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Summary:Androgen-independent prostate cancer accounts for mortality in the world. In this study, various extracts of a medical fungus dubbed Ganoderma formosanum were screened for inhibition of DU145 cells, an androgen-independent prostate cancer cell line. Results demonstrated that both hexane (GF-EH) and butanol (GF-EB) fraction of G. formosanum ethanol extract inhibited DU145 cell viability in a dose-dependent manner. GF-EH induced cell-cycle arrest in G1 phase of DU145 cells via downregulation of cyclin E2 protein expression. In addition, GF-EB triggered extrinsic apoptosis of DU145 cells by activating caspase 3 gene expression resulting in programed cell death. Above all, both GF-EH and GF-EB show lower toxicity to normal human fibroblast cell line compared to DU145 cell, implying that they possess specific drug action on cancer cells. This study provides a molecular basis of G. formosanum extract as a potential ingredient for treatment of androgen-independent prostate cancer.
Bibliography:The Korean Society of Mycology
KISTI1.1003/JNL.JAKO202020550933074
ISSN:1229-8093
2092-9323