공진단(拱辰丹)과 영신초(靈神草), 원지(遠志), 석창포(石菖蒲) 혼합제제의 기억력과 인지기능 개선 및 항불안에 관한 연구

• Published in: 동의신경정신과학회지 Vol. 22; no. 2; pp. 85 - 105
• Main Authors: 최철홍, Cheol Hong Choi, 김수현, Soo Hyun Kim, 정대규, Dae Kyoo Chung
• Format: Journal Article
• Language: Korean
• Published: 대한한방신경정신과학회 30.06.2011
• Subjects: Acorus gramineus; Anxiety; Gongjin-dan; Learning and memory; Polygala japonica; Polygala tenuifolia; Learning and memory; Polygala japonica; Gongjin-dan; Acorus gramineus; Anxiety; Polygala tenuifolia
• ISSN: 1226-6396; 2234-4942

Objectives: The purpose of this study was to characterize the neuroprotective effects and anxiolytic-like effects of Gongjin-dan and Polygala japonica, Polygala tenuifolia, Acorus gramineusmixed pills(G.J.D-P.P.A.). Methods: The neuroprotective effects of G.J.D-P.P.A. determined by the passive avoidance and Y-maze tasks and Morris water maze task, and the anxiolytic-like effects of the G.J.D-P.P.A. using an elevated plus-maze(EPM) in mice. Results: Drug-induced amnesia was induced by treating animals with scopolamine(1 mg/kg, i.p.). A single G.J.D-P.P.A.(400 and 800 mg/kg) administration significantly enhanced cognitive function and attenuated scopolamine-induced cognitive impairments as determined by the passive avoidance and Y-maze tasks(P < 0.05) and also reduced escape-latency on the Morris water maze task(P < 0.05). The administration of GJD-PPA(400 and 800 mg/kg) significantly increased the percentage of time spent in open arms and entries into the open arms of the EPM compared with saline-treated control group(P < 0.05). Moreover, there were no changes in the locomotor activity and myorelaxant effects in any group compared with saline-treated control group. Conclusions: These results suggest that GJD-PPA dramatically possesses the anti-amnestic and cognitive-enhancing activities related to the memory processes, and promotes the anxiolytic-like activity in mice.