잣버섯(Neolentinus lepideus) 에탄올 추출물의 혈당상승 억제 효과

• Published in: Hangug gynnhaghoi ji Vol. 43; no. 3; pp. 174 - 179
• Main Authors: 신자원, Jawon Shin, 배상민, Sangmin Bae, 한상민, Sangmin Han, 이윤혜, Yunhae Lee, 김정한, Jeonghan Kim, 지정현, Jeonghyun Ji, 이종수, Jongsoo Lee
• Format: Journal Article
• Language: Korean
• Published: 한국균학회 30.09.2015
• Subjects: Antihyperglycemic effect; Neolentinus lepideus; α-Glucosidase inhibitor; Neolentinus lepideus; {\alpha}$-Glucosidase inhibitor; Antihyperglycemic effect
• ISSN: 0253-651X; 2383-5249

버섯을 이용하여 새로운 혈당상승 억제 물질을 개발하여 건강 기능성 식품 소재 산업에 응용하고자 느타리버섯, 노랑느타리버섯, 분홍느타리버섯, 새송이버섯과 잣버섯들의 α-glucosidase 저해활성을 측정한 결과 잣버섯 자실체의 에탄올 추출물이 가장 높은 α-glucosidase 저해활성을 보였다. 잣버섯 자실체 분말을 95% 에탄올로 30oC에서48시간 추출하였을 때 α-glucosidase 저해물질이 가장 많이 추출되었고이 α-glucosidase 저해물질을 함유한 잣버섯 에탄올 추출물은 일반 쥐와 streptozotocin으로 당뇨를 유발시킨 당뇨 쥐에서 모두 농도 의존적으로 식후 혈당상승 억제 효과를 보였다. For development a new anti-diabetic compound from edible mushroom, antihyperglycemic α-glucosidase inhibitory activities of Pleurotus ostreatus, Pleurotus cornucopiae, Pleurotus salmoneostramineus, Pleurotus eryngii and Neolentinus lepideus were investigated on its water and ethanol extracts. α-Glucosidase inhibitory activity of Neolentinus lepideus fruiting body showed the highest at 86.3% in the 95% ethanol extracts and water extract from Pleurotus cornucopiae was also higher at 48.5% among water extracts. Therefore, Neolentinus lepideus which showed very high α-glucosidase inhibitory activity was selected as a new anti-diabetic agent-containing mushroom and the α-glucosidase inhibitor was maximally extracted when treated with 95% ethanol at 30oC for 48 hr. The ethanol extracts from Neolentinus lepideus fruiting body showed dosage-dependent hypoglycemic action after administration to 120 min in the SD-rat and streptozotocin-induced diabetic SD-rat.