AMPK Alchemy: Therapeutic Potentials in Allergy, Aging, and Cancer

All cells are equipped with intricate signaling networks to meet the energy demands and respond to the nutrient availability in the body. AMP-activated protein kinase (AMPK) is among the most potent regulators of cellular energy balance. Under ATP -deprived conditions, AMPK phosphorylates substrates...

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Bibliographic Details
Published inBiomolecules & therapeutics Vol. 32; no. 2; pp. 171 - 182
Main Authors Ram Hari Pokhrel, Suman Acharya, Sunil Mishra, Ye Gu, Umar Manzoor, Jeon-kyung Kim, Youngjun Park, Jae-hoon Chang
Format Journal Article
LanguageKorean
Published 한국응용약물학회 01.03.2024
Subjects
Aging
Allergy
AMPK
Cancer
Aging
Allergy
AMPK
Cancer
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Summary:All cells are equipped with intricate signaling networks to meet the energy demands and respond to the nutrient availability in the body. AMP-activated protein kinase (AMPK) is among the most potent regulators of cellular energy balance. Under ATP -deprived conditions, AMPK phosphorylates substrates and affects various biological processes, such as lipid/glucose metabolism and protein synthesis. These actions further affect the cell growth, death, and functions, altering the cellular outcomes in energy-restricted environments. AMPK plays vital roles in maintaining good health. AMPK dysfunction is observed in various chronic diseases, making it a promising target for preventing and alleviating such diseases. Herein, we highlight the different AMPK functions, especially in allergy, aging, and cancer, to facilitate the development of new therapeutic approaches in the future.
Bibliography:The Korean Society of Applied Pharmacology
KISTI1.1003/JNL.JAKO202409443304193
ISSN:1976-9148
2005-4483