Consoramides A-C, New Zwitterionic Alkaloids from the Fungus Irpex consors

• Published in: Mycobiology Vol. 49; no. 4; pp. 434 - 437
• Main Authors: Kim, Ji-Yul, Ki, Dae-Won, Lee, Yoon-Ju, Ha, Lee Su, Woo, E-Eum, Lee, In-Kyoung, Yun, Bong-Sik
• Format: Journal Article
• Language: Korean
• Published: 한국균학회 31.08.2021
• Subjects: Consoramides A-C; Irpex consors; NMR; Zwitterionic alkaloids; Zwitterionic alkaloids; Irpex consors; NMR; Consoramides A-C
• ISSN: 1229-8093; 2092-9323

In our ongoing search for new secondary metabolites from fungi, a basidiomycete fungus Irpex consors was selected for mycochemical investigation, and three new zwitterionic alkaloids (1-3) and five known compounds (4-8) were isolated from the culture broth (16 l) of I. consors. The culture filtrate was fractionated by a series of column chromatography including Diaion HP-20, silica gel, and Sephadex LH-20, Sep-Pak C 18 cartridge, medium pressure liquid chromatography (MPLC), and high pressure liquid chromatography (HPLC) to yield eight compounds (1-8). The structures of the isolated compounds were elucidated by the interpretation of nuclear magnetic resonance (NMR) spectra and high-resolution mass spectrometry (HR-MS). Their antioxidant and antibacterial activities were examined. The zwitterionic structures of three new sesquiterpene alkaloids (1-3) were determined together with five known compounds identified as stereumamide E (4), stereumamide G (5), stereumamide H (6), stereumamide D (7), and sterostrein H (8). This is the first report of the zwitterionic alkaloids in the culture broth of I. consors. Three new zwitterionic alkaloids were named as consoramides A-C (1-3).