Suppressive Effect of Fermented Angelica tenuissima Root Extract against Photoaging: Possible Involvement of Hemeoxygenase-1

• Published in: Journal of microbiology and biotechnology Vol. 28; no. 8; pp. 1391 - 1400
• Main Authors: Park, Yun-A, Lee, Sung Ryul, Lee, Jin Woo, Koo, Hyun Jung, Jang, Seon-A, Yun, Seung-Won, Kim, Hyun Ju, Woo, Jeong Suk, Park, Myung Rye, Kang, Se Chan, Kim, Youn Kyu, Sohn, Eun-Hwa
• Format: Journal Article
• Language: Korean
• Published: 한국미생물생명공학회 31.08.2018
• Subjects: Angelica tenuissima; extracellular matrix; fermentation; hemeoxygenase-1; photoaging; ultraviolet light B; hemeoxygenase-1; fermentation; ultraviolet light B; extracellular matrix; Angelica tenuissima; photoaging
• ISSN: 1017-7825; 1738-8872

Angelica tenuissima root has historically been used as a traditional medicine in Korea. Previous studies have identified the anti-melanogenic effects of the extract of A. tenuissima root fermented by Aspergillus oryzae (FAT). This study investigated the protective effects of FAT against ultraviolet light B exposure (UVB; 30 mJ/㎠) in HaCaT (human keratinocyte) or Hs68 (human foreskin fibroblast) skin cells. FAT treatment was able to stimulate wound healing rate at the basal condition. FAT also favored the maintenance and/or improvement of extracellular matrix impairment caused by UVB irradiation through: 1) upregulation of procollagen Type-1 synthesis and secretion; 2) suppression of MMP-1 and elastase expression. FAT was able to play a role in the attenuation of inflammatory responses caused by UVB irradiation via upregulation of photo-protective hemeoxygease-1 and suppression of proinflammatory cyclooxygenase-2 expression. After further verification of the anti-photoaging potential of FAT, it could be utilized as an effective ingredient in anti-aging and anti-wrinkle cosmetics.