Development of Non-Immunosuppressive FK506 Derivatives as Antifungal and Neurotrophic Agents

FK506, also known as tacrolimus, is a clinically important immunosuppressant drug and has promising therapeutic potentials owing to its antifungal, neuroprotective, and neuroregenerative activities. To generate various FK506 derivatives, the structure of FK506 has been modified by chemical methods o...

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Bibliographic Details
Published inJournal of microbiology and biotechnology Vol. 30; no. 1; pp. 1 - 10
Main Authors Jung, Jin A, Yoon, Yeo Joon
Format Journal Article
LanguageKorean
Published 한국미생물생명공학회 31.01.2020
Subjects
antifungal activity
biosynthesis
FK506
neurotrophic activity
FK506
neurotrophic activity
antifungal activity
biosynthesis
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Summary:FK506, also known as tacrolimus, is a clinically important immunosuppressant drug and has promising therapeutic potentials owing to its antifungal, neuroprotective, and neuroregenerative activities. To generate various FK506 derivatives, the structure of FK506 has been modified by chemical methods or biosynthetic pathway engineering. Herein, we describe the mode of the antifungal action of FK506 and the structure-activity relationship of FK506 derivatives in the context of immunosuppressive and antifungal activities. In addition, we discuss the neurotrophic mechanism of FK506 known to date, along with the neurotrophic FK506 derivatives with significantly reduced immunosuppressive activity. This review suggests the possibility to generate novel FK506 derivatives as antifungal as well as neuroregenerative/neuroprotective agents.
Bibliography:The Korean Society for Applied Microbiology
KISTI1.1003/JNL.JAKO202011563174791
ISSN:1017-7825
1738-8872