유기인계 농약 중독환자에서 기계환기 필요성에 대한 예측인자 분석

• Published in: 대한임상독성학회지 Vol. 8; no. 2; pp. 106 - 112
• Main Authors: 박동찬, Dong Chan Park, 박정배, Jung Bae Park, 김윤정, Yun Jeong Kim, 신수정, Soo Jeong Shin, 문유호, You Ho Mun, 박신률, Sin Ryul Park, 류현욱, Hyun Wook Ryoo, 서강석, Kang Suk Seo, 정제명, Jae Myung Chung
• Format: Journal Article
• Language: Korean
• Published: 대한임상독성학회 30.12.2010
• Subjects: APACHE II score; Cholinesterase; Mechanical ventilation; Organophosphate intoxication; APACHE II score; Mechanical ventilation; Organophosphate intoxication; Cholinesterase
• ISSN: 1738-1320; 2508-6332

Purpose: The purpose of this study is to investigate the factors that predict using mechanical ventilation for patients with organophosphate intoxication. Methods: We retrospectively reviewed the medical records of 111 patients with acute organophosphate intoxication and who were treated in our emergency center from January 2000 to December 2008. We compared the toxicologic characteristics, the laboratory findings and the APACHE II scores between the Mechanical Ventilation group (MV group) and the non-Mechanical Ventilation group (the non MV group). Results: Sixty three patients were in the MV group and 48 patients were in the non MV group. In the MV group, the patients had an older age (p<0.001), a larger amount of ingestion (p<0.001), a lower initial serum cholinesterase level (p=0.003), a higher APACHE II score (p<0.001) and they ingested a more toxic agent (p=0.001). There were no significant differences in gender, the type of visit and the arrival time between the MV group and the non MV group. Conclusion: We suggest that the patient’s age, the amount of organophosphate ingestion, the toxicity of the agent, the initial serum cholinesterase level and the APACHE II score are important factors to determine if mechanical ventilation will be applied for patients with organophosphate intoxication.