당귀보혈탕(當歸補血湯)의 SD계 흰쥐에 대한 아급성경구독성시험

• Published in: 大韓本草學會誌 Vol. 21; no. 2; pp. 159 - 163
• Main Authors: 강순아, Soon Ah Kang, 장문석, Mun Seog Chang, 오명숙, Myung Sook Oh, 박완수, Wan Su Park, 김원남, Won Nam Kim, 양웅모, Woong Mo Yang, 이병희, Byong Hee Lee, 박성규, Seong Kyu Park
• Format: Journal Article
• Language: Korean
• Published: 대한본초학회 30.06.2006
• Subjects: body weights; clinical signs; Dangguibohyel-tang; DBT; subacute toxicity; body weights; subacute toxicity; clinical signs; Dangguibohyel-tang (DBT)
• ISSN: 1229-1765

Objectives : The subacute toxicity was investigated in Sprague-Dawley rats orally treated with Dangguibohyel-tang (DBT). DBT has been used for anemia, in Korean medicine. Methods : Sprague-Dawley rats were administered orally with DBT at the dosages of 1,000 mg/kg for 14 days. We daily examined number of deaths, clinical signs, body weights and gross findings during the 14 days. Results : There were no clinical signs and pathological changes compared with control group. Body weights were not significantly changed between control and treatment groups. In hematological and biochemical serum parameters, all mean values appear to be within the normal range. Conclusion : These results suggest that DBT dose not induce any significant subacute oral toxicities in Sprague-Dawley rats.