Long-Term Outcomes of Adult Lung Transplantation Recipients: A Single-Center Experience in South Korea

• Published in: Tuberculosis and respiratory diseases Vol. 82; no. 4; pp. 348 - 356
• Main Authors: Jo, Kyung-Wook, Hong, Sang-Bum, Kim, Dong Kwan, Jung, Sung Ho, Kim, Hyeong Ryul, Choi, Se Hoon, Lee, Geun Dong, Lee, Sang-Oh, Do, Kyung-Hyun, Chae, Eun Jin, Choi, In-Cheol, Choi, Dae-Kee, Kim, In Ok, Park, Seung-Il, Shim, Tae Sun
• Format: Journal Article
• Language: Korean
• Published: 대한결핵 및 호흡기학회 01.10.2019
• Subjects: Chronic Kidney Disease; Chronic Lung Allograft Dysfunction; Lung Transplantation; Survival; Lung Transplantation; Chronic Lung Allograft Dysfunction; Chronic Kidney Disease; Survival
• ISSN: 1738-3536; 2005-6184

Background: Recently, the number of lung transplants in South Korea has increased. However, the long-term outcome data is limited. In this study, we aimed to investigate the long-term outcomes of adult lung transplantation recipients. Methods: Among the patients that underwent lung transplantation at a tertiary referral center in South Korea between 2008 and 2017, adults patient who underwent deceased-donor lung transplantation with available follow-up data were enrolled. Their medical records were retrospectively reviewed. Results: Through eligibility screening, we identified 60 adult patients that underwent lung (n=51) or heart-lung transplantation (n=9) during the observation period. Idiopathic pulmonary fibrosis (46.7%, 28/60) was the most frequent cause of lung transplantation. For all the 60 patients, the median follow-up duration for post-transplantation was 2.6 years (range, 0.01-7.6). During the post-transplantation follow-up period, 19 patients (31.7%) died at a median duration of 194 days. The survival rates were 75.5%, 67.6%, and 61.8% at 1 year, 3 years, and 5 years, respectively. Out of the 60 patients, 8 (13.3%) were diagnosed with chronic lung allograft dysfunction (CLAD), after a mean duration of 3.3±2.8 years post-transplantation. The CLAD development rate was 0%, 17.7%, and 25.8% at 1 year, 3 years, and 5 years, respectively. The most common newly developed post-transplantation comorbidity was the chronic kidney disease (CKD; 54.0%), followed by diabetes mellitus (25.9%). Conclusion: Among the adult lung transplantation recipients at a South Korea tertiary referral center, the long-term survival rates were favorable. The proportion of patients who developed CLAD was not substantial. CKD was the most common post-transplantation comorbidity.