한국인의 비만과 인슐린비의존성당뇨병에서 베타-2 아드레날린 수용체 유전자 다형성

• Published in: The Korean journal of medicine Vol. 56; no. 4; pp. 474 - 488
• Main Authors: 김병준, Byoung Joon Kim, 안규정, Kyu Jeong Ahn, 김영설, 최영길, 이문규, 김성훈, Sung Hoon Kim, 김동준, Dong Jun Kim, 함종렬, Jong Ryeal Hahm, 정재훈, Jae Hoon Chung, 민용기, Yong Ki Min, 이명식, Myung Shik Lee, 김광원, Kwang Won Kim
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.04.1999
• Subjects: beta-2 adrenergic receptor gene polymorphism; NIDDM; obesity
• ISSN: 1738-9364

Objective: Catecholamine play a central role in the regulation of energy expenditure, in part by stimulating lipid mobilization through lipolysis in fat cells. The beta-2 adrenergic receptor(BAR-2) is a major lipolytic receptor in human fat cells. A recent study has shown that common polymorphisms occuring at codon 16 and 27 of the BAR-2 gene are significantly associated with obesity and lypolytic BAR-2 function in adipose tissue. We investigated whether the previously described human BAR-2 gene polymorphisms are associated with obesiy and NIDDM in Koreans. Methods : All subjests were divided into two groups, non-obese and obese group, according to their body mass index. And their clinical characteristics were evaluated. The BAR-2 gene polymorphisms were analyzed by PCR-RFLP in 89 nondiabetics and 106 patients with NIDDM. Results : When the allele frequency of BAR-2 gene polymorphisms was compared with that of western people, there was a significant difference. In our study, there was no significant difference in the allele frequency of BAR-2 gene polymorphisms at codons 16 and 27 between nonobese and obese group both nondiabetics and NIDDM subjects. The frequency of Glu27 homozygotes was very rare(1.1%). Body mass index(BMI), waist-hip ratio(WHR), and serum glucose and insulin secretion of the nondiabetics with polymorphism of codon 16 or codon 27 did not differ from those of the subjects without the polymorphisms. In NIDDM group, the Gly16 homozygotes had a lower BMI than Arg16 homozygotes without any difference in WHR and the other laboratory parameters. Neither clinical or laboratory parameters of the diabetics with the polymorphism at codon 27 differ from those of subjectes without the polymorphism. Conclusion : These findings suggest that the genetic variability in the human BAR-2 gene is not a major determinant for the development of obesity and NIDDM in Koreans.