비소세포 폐암에서의 EGFR 의 발현 양상

• Published in: The Korean journal of medicine Vol. 48; no. 4; pp. 428 - 434
• Main Authors: 손경선, Kyung Sun Son, 조해정, Hai Jeong Cho, 김애경, Ae Kyoung Kim, 이종진, Jong Jin Lee, 한표성, Pyo Seong Han, 김주옥, Ju Ock Kim, 김선영, Sun Young Kim
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.04.1995
• Subjects: EGFR; Non - small cell lung cance
• ISSN: 1738-9364

Objectives: EGFR is a transmembrane molecule and is characterized by tyrosine protein kinase activity and ligand-stimulated autophosphorylation. It was found in various cell types including fibroblast and keratinocytes. EGFR appears to have an important role in the development and proliferation of certain human malignancies, including those of neuroglia, bladder, and breast. The heterogeneity of EGFR expression is known to be related with proliferating fraction, histological grade, and susceptibility of anti- cancer drugs, etc. We investigated the biologic significance of the expression of EGFR in lung cancer tissues. Methods: The expression of EGFR was assessed immunohistochemically on paraffin imbedded lung cancer tissues including 28 primary sites with 16 lymph nodes using monoclonal antibody and indirect peroxidase technique. Results: 1) EGFR expression of primary tumor in squamous cell carcinoma was higher than in the others. 2) EGFR expression of primary tumor in stage III was higher than in stage I and stage II. 3) EGFR expression rates of primary and metastatic sites were 60.7% and 61.1%, respectively. No significant difference between primary site and metastatic one was noticed. 4) EGFR expression rates in primary tumor with metastasis was 64.7% and without metastasis was 54.5%. 5) EGFR expression rates of lung cancer by nodal stage were 50% in N1 and 60% in N2. But significant difference among nodal stages was not noticed. 6) EGFR expression rates of lymph nodes according to EGFR positivity of primary tumor were 50% in lymph nodes that have negative steins in lungs and 60% in lymph nodes that have positive stains in lungs. 7) No significant difference in 12-month survival between positive group and negative group was noticed. Conclusion: EGFR expression of routinely processed tissue is a simple technique for the assessment of cell growth and terminal differentiation in non small cell lung cancer. Whether EGFR expression has an independent prognostic value and deserves special attention in pathobiological evaluation in lung cancer remains to be investigated from large series with longer follow - up and to be correlated with multiple biological markers.