Desflurane 의 흡입농도에 따른 Bispectral Index 의 변화

• Published in: Korean journal of anesthesiology Vol. 41; no. 3; pp. 280 - 283
• Main Authors: 길호영, Ho Yeong Kil, 홍성준, Seong Jun Hong, 채봉수, Bong Soo Chae, 박훈, Hoon Park, 한태현, Tae Hyun Han, 이현화, Hyun Hwa Lee
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회(구 대한마취과학회) 30.09.2001
• Subjects: Anesthetics; bispectral index; desflurane; Monitoring; volatile
• ISSN: 2005-6419; 2005-7563

Background: The bispectral index (BIS) has been designed to objectively measure the degree of sedation and hypnosis for several anesthetics. The aim of this study was to evaluate the changes of the BIS during desflurane-N2O-O2 anesthesia. Methods: With Institutional Review Board approval and informed consent, forty premedicated (atropine 0.5 mg, IM) male and female adult patients (ASA class 1 or 2, 18-55 yrs) scheduled for elective surgery were studied. After intubation with the aid of propofol (2.0 mg/kg) and vecuronium (0.15 mg/kg), anesthesia was maintained with desflurane in combination with 50% N2O and 50% O2, Several transitions between 3.0 and 12.0 vol% were performed. During anesthesia, the BIS was checked at least 30 min after induction to avoid the residual effect of propofol and after 15 min maintenance of a certain inhaled concentration for equilibration. Results: The values of BIS were correlated closely with the desflurane concentrations (r =-0.88). Steep changes in the BIS were shown between 1.5-6.0 vol% and a ceiling effect regarding the BIS over 6.0 vol% was observed. Conclusions: The BIS is valuable for measuring the degree of sedaton and hypnosis in desflurane anesthesia. Above 6.0 vo1%, desflurane showed a ceiling effect regarding the BIS. (Korean J Anesthesiol 2001; 41: 280-283)